Comments on: Thiazides first for hypertension? http://www.prescriber.org.uk/2008/01/30/thiazides-first-for-hypertension/ An NHS Prescribing Advisers' Blog Fri, 05 Sep 2008 22:39:42 +0000 http://wordpress.org/?v=2.6.1 By: Matthew Robinson http://www.prescriber.org.uk/2008/01/30/thiazides-first-for-hypertension/#comment-2421 Matthew Robinson Wed, 06 Feb 2008 09:59:13 +0000 http://www.prescriber.org.uk/2008/01/30/thiazides-first-for-hypertension/#comment-2421 Minto, This analysis was conducted on the ALLHAT study which used chlorthalidone as the thiazide drug for the study. This choice is based on market share usage in America. In Britain, bendroflumethiazide is the most popular thiazide and of course it was studied in ASCOT. Of course ASCOT wasn't as favourable in terms of outcomes but there are limitations to the study when looking at the doses of thiazide and beta blocker used. Additionally, indapamide has been studied in the PROGRESS study. So, should you continue to use what you know and are comfortable with or changed to the thiazide used in ALLHAT. There is no clear evidence that there are differences between these drugs so continuing with bendroflumethiazide would seem a rational choice. Minto,

This analysis was conducted on the ALLHAT study which used chlorthalidone as the thiazide drug for the study. This choice is based on market share usage in America.

In Britain, bendroflumethiazide is the most popular thiazide and of course it was studied in ASCOT. Of course ASCOT wasn’t as favourable in terms of outcomes but there are limitations to the study when looking at the doses of thiazide and beta blocker used. Additionally, indapamide has been studied in the PROGRESS study.

So, should you continue to use what you know and are comfortable with or changed to the thiazide used in ALLHAT. There is no clear evidence that there are differences between these drugs so continuing with bendroflumethiazide would seem a rational choice.

]]> By: minto http://www.prescriber.org.uk/2008/01/30/thiazides-first-for-hypertension/#comment-2420 minto Tue, 05 Feb 2008 23:53:19 +0000 http://www.prescriber.org.uk/2008/01/30/thiazides-first-for-hypertension/#comment-2420 the subgroup analysis supports the use of chlorthalidone. however is this a class effect and is bendroflumethiazide the same? are all thiazide diuretics the same? where is the evidence for bendroflumethiazide? the subgroup analysis supports the use of chlorthalidone. however is this a class effect and is bendroflumethiazide the same? are all thiazide diuretics the same? where is the evidence for bendroflumethiazide?

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