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Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog


Tramacet has been launched recently and is being heavily promoted in the form of adverts and journal inserts. It contains 325mg of Paracetamol and 37.5mg of Tramadol per tablet.

Given the recent announcement of the withdrawal of Co-proxamol, we feel it would be inappropriate to transfer patients to this drug. We are also concerned that this new product contains subtherapeutic doses of both ingredients.

It currently costs £10.07 for 60 tablets which is over £9 more than the cost of 100 Paracetamol and £3 more than 100 Co-codamol 30/500mg tablets.

Action: There can be no good reason to use Tramacet in any circumstance.

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108 Comments to “Tramacet”

  1. This advice is misleading. There are conditions for which low combined doses of Tramadol and Paracetamol are both therapeutic and necessary.

    Comment by misspiggy — June 10, 2021 #

    1. @Misspiggy, The advice above is an opinion based on the costs of these products, available comparator products and an assessment of the product characteristics. I'm not sure why you feel my opinion of misleading while yours is correct, especially when you provide no evidence to support your statement - what conditions are you referring to and where is the trial work?

      Comment by Matthew Robinson — June 10, 2021 #

  2. I took 4 tramacet 37.5mg for post operative pain in my knee. Was it to much?

    Comment by Michelle — January 14, 2020 #

    1. @Michelle,

      If you took all 4 at the same time then yes, that was too much paracetamol. Each Tramacet contains 37.5mg of tramadol and 325mg of paracetamol. By taking 4 you took 150mg of tramadol and 1,300mg of paracetamol. The maximum single dose of paracetamol is 1,000mg.

      If you did this once, and a while ago it is unlikely you did any long term harm. If you've done it a few times and recently you should speak to your doctor.

      Comment by Matthew Robinson — January 14, 2020 #

  3. I am taking tramacet for pain after I was involved in a car accident. I have noticed that I no longer have palpitations, but once I have stop taking it the palpitations returns. Do I have to take them for life. I am afraid for my liver and my kidneys.

    Comment by Nolitha makapela — August 17, 2019 #

    1. @Nolitha Makapela,

      You don't have to take them for life, but you need to speak to your doctor or pharmacist about gradually reducing your dose to avoid withdrawal effects, or at least make it more tolerable until it settles again. It may also be worth investigating the cause of your palpitations if that keeps occurring.

      Comment by Matthew Robinson — August 18, 2019 #

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