The Summary of Product Characteristics for Ezetimibe (Ezetrol) has been updated recently following notification of some rare adverse events in patients taking this drug.
There have been reports of myopathy and rhabdomyolysis, most of these were in patients who were also taking a statin although some were on monotherapy with Ezetimibe.
Additionally, hepatitis has been reported as well as interactions with Warfarin and Ciclosporin.
Action: Patients on Ezetimibe should be informed to notify a clinician of any unexplained muscle pain or weakness. If myopathy is suspected then all drugs likely to be causal should be stopped (including statins and Ezetimibe).
Patients who are on Warfarin or Ciclosporin should be carefully monitored (for INR and therapeutic blood level respectively) during treatment with Ezetimibe.