The editorial on the ASCOT Study reaches the conclusion that the current NICE Hypertension Guideline should be followed until it is updated. The same advice has already been given in a previous article on this site.
A Cochrane systematic review of 32 clinical trials involving 9,605 patients has shown that 3 days treatment with trimethoprim is effective in attaining symptomatic cure from urinary tract infections (UTIs) in non-pregnant women aged between 18 and 65. Longer courses are required for bacteriological cures but are associated with more adverse effects. 3-day courses are already recommended by the Standing Medical Advisory Committee (SMAC) and the Health Protection Agency (HPA). The Cochrane Review supports the continued use of 3-day courses with longer courses reserved for patients where bacterial eradication is necessary, for example in recurrent infections or where the patient is planning pregnancy.
Action: Clinicians who are involved in treating hypertension, UTIs or children are encouraged to read the appropriate sections of this publication.