- Prescribing Advice for GPs - https://www.prescriber.org.uk -

Celecoxib may increase MI risk

A systematic review published in the Journal of the Royal Society of Medicine has concluded that celecoxib (Celebrex)® increases the risk of myocardial infarction.

These findings are duplicated in another paper investigating the efficacy and upper GI tolerability of celecoxib versus diclofenac or naproxen.

The findings in both papers are not statistically significant and the latter study was not designed to detect these differences. Despite this the MHRA have issued a statement reminding clinicians of the current recommendations issued in 2005.

The recommendations are as follows:

Action: Clinicians should be follow of the MHRA recommendations in relation to COX-2 inhibitor and NSAID prescribing.