Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

CHARISMA Lacking

The CHARISMA Study has been made available online by the New England Journal of Medicine.

The study compared clopidogrel and aspirin to aspirin alone in 15,603 patients who had clinical cardiovascular disease or were at high risk of suffering a first event. These patients were then followed up for about 2 years for myocardial infarction, stroke or cardiovascular death.

At the end of the study there was no significant difference between the two groups in the primary outcome. There was a tendency to harm in the group that received clopidogrel and aspirin as there were a greater number of cases of severe bleeding, however this was not statistically significant.

Clopidogrel and aspirin therapy is of benefit in certain situations such as following a stent insertion but this study demonstrates that there is no reason to add clopidogrel to aspirin therapy as there is no incremental benefit for the patient but there may be an increased risk of harm.

Action: Clinicians who prescribe antiplatelets for primary and secondary prevention of uncomplicated cardiovascular disease should avoid using clopidogrel and aspirin in combination.

Share 'CHARISMA Lacking' on Email Share 'CHARISMA Lacking' on Delicious Share 'CHARISMA Lacking' on Digg Share 'CHARISMA Lacking' on Facebook Share 'CHARISMA Lacking' on Google+ Share 'CHARISMA Lacking' on reddit Share 'CHARISMA Lacking' on StumbleUpon Share 'CHARISMA Lacking' on Twitter

atomic-wealth

No Comments to “CHARISMA Lacking”

Leave a Comment

(required)

(required)


Prescribing Advice for GPs is powered by WordPress.
Subscribe for Free to our RSS or Atom Feeds for New Entries.
Akismet has protected Prescribing Advice for GPs from 789,664 spam comments.

atomic-wealth
fond-illness
summer