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Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

Doxepin discontinued

Doxepin (Sinequan)® capsules are being discontinued in all strengths according to the National Electronic Library for Medicines.

Doxepin is a tricyclic antidepressant with sedative properties. It is expected that supplies will be exhausted by October 2006 although some strengths may disappear sooner.

Doxepin is not widely used but is not available generically and therefore alternative products will need to be used if treatment needs to continue. Amitryptiline, Dosulepin or Clomipramine may be suitable choices.

Action: Clinicians should be aware of this products discontinuation and may wish to identify individuals currently taking this drug. Alternative treatments will need to be investigated if treatment will continue beyond October 2006.

Update: In early 2022 several generic manufacturers are continuing to supply doxepin in the UK. It appears to be readily available in 25mg and 50mg strengths.

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66 Comments to “Doxepin discontinued”

  1. The VA has me on 100mg of doxepin nightly! I've been prescribed up to 150mg of doxepin before the doctor cut it down to 100mg. This drug doesn't work for me! I've taken almost every other drug used for sleep however none of them worked. Those drugs were mainly anti-histamines. Take doxepin at 6pm nightly, I'm lucky if I fall asleep before 1am then I'm wide awake again between 5-6 am. This has been going on for quite a few years and I'm tired of being tired! I'm 74 and in excellent health, don't drink or do drugs anymore (since 2006), and would love to get a full night's sleep!

    Comment by Fred Farkleshine — April 19, 2022 #

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