Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

Ibuprofen Isomer

Dexibuprofen (Seractil)® has been launched in the United Kingdom. It is the active isomer of Ibuprofen.

It is available in 300mg and 400mg tablets, priced at £9.47 for 60 tablets. According to the Summary of Product Characteristics is has been shown to be non-inferior to Ibuprofen in osteoarthritis and dysmenorrhoea over short periods.

Based on current prices it is at least 50% more expensive that Ibuprofen and is likely to cause side effects of dyspepsia or diarrhoea in over 10% of patients. At normal doses this product is also more expensive that diclofenac and naproxen.

Action: Based on the increased cost and lack of evidence for superior efficacy over Ibuprofen there is no reason to use this drug before current first choice options of Ibuprofen, Diclofenac and Naproxen as recommended in the Formulary.

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