Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

More Antihypertensive Data

The National Electronic Library for Medicines has reported on two recent papers regarding hypertension.

Circulation has published an analysis of the ALLHAT study and each of the study medications preventative effects on heart failure. This paper found that diuretics were better than calcium channels blockers at preventing heart failure. Diuretics were also superior to ACE Inhibitors in the short term.

Diabetes Care has published the results of a prospective cohort study into the association between different antihypertensive agents and the development of diabetes. There is also an editorial to accompany this paper. The paper concludes that thiazide diuretics and beta-blockers are associated with an increased risk of diabetes and therefore patients on these drugs should be monitored more closely.

The editorial questions if the increased risks of developing diabetes detracts from the cardiovascular benefits. ALLHAT for example compared chlorthalidone, lisinopril and amlodipine, all of these drugs reduced cardiovascular outcomes to a similar extent despite chlorthalidone being associated with higher rates of new-onset diabetes.

Action: This new information will be of interest to clinicians treating hypertension. The NICE Guidance on Hypertension is expected this month and changing current practice at this stage would be unwise.

Share 'More Antihypertensive Data' on Email Share 'More Antihypertensive Data' on Delicious Share 'More Antihypertensive Data' on Digg Share 'More Antihypertensive Data' on Facebook Share 'More Antihypertensive Data' on Google+ Share 'More Antihypertensive Data' on reddit Share 'More Antihypertensive Data' on StumbleUpon Share 'More Antihypertensive Data' on Twitter

atomic-wealth

No Comments to “More Antihypertensive Data”

Leave a Comment

(required)

(required)


Prescribing Advice for GPs is powered by WordPress.
Subscribe for Free to our RSS or Atom Feeds for New Entries.
Akismet has protected Prescribing Advice for GPs from 789,523 spam comments.

atomic-wealth
fond-illness
summer