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The topic of the first Rapid Review is the results of the ESPRIT Study. This study was prospective and randomised by design and examined the primary composite outcome of death from all vascular causes, non-fatal stroke, non-fatal myocardial infarction (MI), or major bleeding complications. Patients were randomised to aspirin (30-325mg daily, mean 75mg) with or without dipyridamole (200mg twice daily).
The result was that significantly fewer patients in the dipyridamole arm had a primary outcome event compared to those in the aspirin only arm. This finding supports the recommendations in the NICE Guidance on Vascular Disease - Clopidogrel and dipyridamole.
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