MTRAC review Cox-II NSAIDs
The Midlands Therapeutic Review and Advisory Committee (MTRAC) has reviewed the evidence for the three Cox-II NSAIDs.
They have issued review on:
- Celecoxib (Celebrex®)
- Etoricoxib (Arcoxia®)
- Lumiracoxib (Prexige®)
The reviews covered 25 randomised controlled studies involving celecoxib, 13 involving etoricoxib and 8 involving lumiracoxib. All three reviews found that evidence of efficacy for these drugs was strong but concerns about cardiovascular safety gives this class of drugs a low place in therapy.
Action: These review provide a useful summary and reminder of the efficacy and safety evidence for Cox-II NSAIDs.
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