Prescribing Advice for GPs

MTRAC review Cox-II NSAIDs

August 3, 2006 at 3:57 pm | In Prescribing Extra - Drugs | Print | No Comments

The Midlands Therapeutic Review and Advisory Committee (MTRAC) has reviewed the evidence for the three Cox-II NSAIDs.

They have issued review on:

• Celecoxib (Celebrex^®)
• Etoricoxib (Arcoxia^®)
• Lumiracoxib (Prexige^®)

The reviews covered 25 randomised controlled studies involving celecoxib, 13 involving etoricoxib and 8 involving lumiracoxib. All three reviews found that evidence of efficacy for these drugs was strong but concerns about cardiovascular safety gives this class of drugs a low place in therapy.

Action: These review provide a useful summary and reminder of the efficacy and safety evidence for Cox-II NSAIDs.