Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

MTRAC review Cox-II NSAIDs

The Midlands Therapeutic Review and Advisory Committee (MTRAC) has reviewed the evidence for the three Cox-II NSAIDs.

They have issued review on:

The reviews covered 25 randomised controlled studies involving celecoxib, 13 involving etoricoxib and 8 involving lumiracoxib. All three reviews found that evidence of efficacy for these drugs was strong but concerns about cardiovascular safety gives this class of drugs a low place in therapy.

Action: These review provide a useful summary and reminder of the efficacy and safety evidence for Cox-II NSAIDs.

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