Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

NELM reviews ADOPT Study

The National Electronic Library for Medicines has published an 'In-Focus' review of ADOPT (A Diabetes Outcome Progression Trial).

As previously reported, this study does not provide compelling evidence to change current practice away from using metformin first-line.

This review provides a thorough evaluation of the trial and highlights many issues raised by this trial that need further work, including those previously covered here. Additionally, this review highlighted weight gain as an adverse effect observed in the rosiglitazone group. At four years follow-up there was a difference of almost 7kg between patients taking rosiglitazone compared to those taking metformin. Some of this weight gain may be due to fluid retention but in already obese individuals this is still a cause for concern.

This review also concludes that metformin remains first-line based especially after consideration of cost. At the maximum doses used in the trial rosiglitazone would cost £49.48 per month compared to metformin at £3.60.

Action: Metformin continues to be the first-line hypoglycaemic for type 2 diabetes.

Share 'NELM reviews ADOPT Study' on Email Share 'NELM reviews ADOPT Study' on Delicious Share 'NELM reviews ADOPT Study' on Digg Share 'NELM reviews ADOPT Study' on Facebook Share 'NELM reviews ADOPT Study' on Google+ Share 'NELM reviews ADOPT Study' on reddit Share 'NELM reviews ADOPT Study' on StumbleUpon Share 'NELM reviews ADOPT Study' on Twitter

atomic-wealth

One Comments to “NELM reviews ADOPT Study”

  1. […] The manufacturer of rosiglitazone (Avandia® and Avandamet®) has written to healthcare professionals to highlight the increased risk of fractures identified in the ADOPT Study. […]

    Pingback by Rosiglitazone And Increased Risk Of Fracture | Prescribing Advice For GPs — March 15, 2007 #
    Reply

Leave a Comment

(required)

(required)


Prescribing Advice for GPs is powered by WordPress.
Subscribe for Free to our RSS or Atom Feeds for New Entries.
Akismet has protected Prescribing Advice for GPs from 789,905 spam comments.

atomic-wealth
fond-illness
summer