- Prescribing Advice for GPs - https://www.prescriber.org.uk -

JBS2 contain serious deficiencies

The International Journal of Clinical Practice has published a paper assessing the quality of the second Joint British Societies' guidelines on the prevention of cardiovascular disease (JBS2).

These are the guidelines that have been used to promote lower cholesterol targets of 4mmol/L for total cholesterol (TC) and 2mmol/L for low-density lipoprotein cholesterol (LDL-C). As previously discussed, National Policy has been clarified and recommends targets of 5mmol/L for TC and 3mmol/L for LDL-C.

Recognised criteria for reviewing the quality of guidelines (Appraisal of Guidelines Research and Evaluation) were used to evaluate JBS2. In summary it was found that these guidelines "contain serious deficiencies, are of low quality and should not be recommended for clinical practice".

Action: National Policy is clear, current cholesterol targets remain at 5mmol/L for TC and 3mmol/L for LDL-C. Given the criticism of JBS2, it would seem prudent to view recommendations based upon this guideline with some scepticism.