Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

Safety review of glitazones complete

The Medicines and Healthcare products Regulatory Agency have announced the outcome of a Europe wide safety review of the glitazones.

The review found a positive benefit-risk balance for both pioglitazone and rosiglitazone. However, prescribing information should be updated for the latter drug to indicate that it should only be used in patients with ischaemic heart disease only after a careful evaluation of the patient's individual risk and that it should only be used in combination with insulin in exceptional cases and under close supervision.

Action: Clinicians should be aware of the outcome of this review and the new cautions added to the prescribing information for rosiglitazone. Metformin and sulphonylureas remain the oral hypoglycaemics of choice, pioglitazone may be an alternative to these drugs in case of intolerance or where contraindications exist.

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2 Comments to “Safety review of glitazones complete”

  1. [...] will already be well aware of the safety concerns linking rosiglitazone with heart attacks. Updated prescribing information advises against using [...]

    Pingback by Prescribing Advice For GPs » ADA/EASD Advise Against Rosiglitazone — October 23, 2008 #
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  2. [...] new warnings are more restrictive than previous advice that recommended careful evaluation of the patient’s individual [...]

    Pingback by Prescribing Advice For GPs » Rosiglitazone Prescribing Information Updated — April 25, 2008 #
    Reply

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