Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

Lumiracoxib licence suspended

The Medicines and Healthcare products Regulatory Agency has suspended the licence for lumiracoxib (Prexige®) according to a press release.

Earlier this year restrictions were introduced following safety concerns about possible liver damage. A review of the most recent worldwide data has shown that liver reactions have occurred in patients taking low doses and for short periods.

Patients who are taking lumiracoxib and who feel well may continue with treatment but are advised to book a non urgent appointment to discuss alternative treatments. Patients taking the drug who feel unwell (particularly nausea, vomiting, loss of appetite, tiredness, stomach pains, dark urine, or itching or yellowing of the skin [jaundice]) are advised to stop treatment immediately.

Action: Clinicians should be aware of this licence suspension. Patients will need their treatment reviewed and a suitable alternative should be prescribed.

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3 Comments to “Lumiracoxib licence suspended”

  1. [...] In addition, this issue contains hot topics focussing on potential side effects of varenicline and balancing of cardiovascular and gastrointestinal risks of NSAIDs. There is also a reminder to prescribers about the withdrawal of lumiracoxib and the risk of severe allergic reactions with strontium ranelate. [...]

    Pingback by Prescribing Advice For GPs » Drug Safety Update, Issue 5 — December 4, 2007 #
    Reply

  2. […] gastrointestinal risks of NSAIDs. There is also a reminder to prescribers about the withdrawal of lumiracoxib and the risk of severe allergic reactions with strontium […]

    Pingback by Drug Safety Update, Issue 5 | Prescribing Advice For GPs — December 4, 2007 #
    Reply

  3. Novartis - Prexige: all systems stop!

    The UK's Medicines and Healthcare products Regulatory Agency has suspended the licence for lumiracoxib (Prexige) according to a press release.

    Trackback by Trusted.MD Network — November 19, 2007 #
    Reply

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