Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

Rosiglitazone prescribing information updated

The European Medicines Agency (EMEA) has recommended (PDF) new warnings and contraindications for rosiglitazone after it adopted the October 2007 findings of the Committee for Medicinal Products for Human Use (CHMP).

The CHMP recommended that rosiglitazone:

  • Must not be used in patients with an acute coronary syndrome, such as angina or some types of myocardial infarction
  • Should be avoided in patients with ischaemic heart disease and/or peripheral arterial disease

These new warnings are more restrictive than previous advice that recommended careful evaluation of the patient's individual risk.

Action: Clinicians should be aware of these new recommendations and ensure that patients who remain on treatment with rosiglitazone are not contraindicated following this update.

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2 Comments to “Rosiglitazone prescribing information updated”

  1. […] will already be well aware of the safety concerns linking rosiglitazone with heart attacks. Updated prescribing information advises against using rosiglitazone in specific patients including acute coronary syndrome and […]

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