- Prescribing Advice for GPs - https://www.prescriber.org.uk -

Varenicline and serious neuropsychiatric symptoms

The Food and Drugs Administration in America has issued a Public Health Advisory that warns of serious neuropsychiatric symptoms associated with treatment.

An on-going review has concluded that, "it appears increasingly likely that there is an association between varenicline and serious neuropsychiatric symptoms".

Patients and their carers have been warned to:

Action: Clinicians should be aware of these safety concerns. Treatment should be stopped immediately if a patient develops neuropsychiatric symptoms. Clinicians should also be aware that these symptoms have developed in some patients after treatment was stopped.