In this instance a 55 year old women was prescribed co-amoxiclav for pneumonia. After the first dose she became disorientated and confused. After transfer to hospital she recovered but deteriorated again after being given a second dose.
Recovery was complete following treatment with antipsychotics. The authors note previous reports of psychiatric adverse effects with co-amoxiclav and also with amoxicillin. They also advised that drug-induced psychosis should be considered, even in the absence of pre-existing psychiatric illness or predisposing factors, in patients developing psychosis after starting treatment with amoxicillin.
Action: Clinicians should be aware of the serious but rare adverse drug reaction.
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