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Drug Safety Update - July 2009

The Medicines and Healthcare products Regulatory Agency (MHRA) has published Drug Safety Update for July 2009 (PDF).

This issue contains advice that the combination of clopidogrel and PPIs should be avoided unless considered essential due to an interaction that reduces efficacy of the clopidogrel. The evidence of clinical significance is not entirely conclusive but the needs for each of these drugs should be assessed and an alternative used where possible. Clinicians should consider if aspirin might be a suitable antithrombotic or if the PPI is still necessary.

The hot topic reviews the current risk-benefit ratio for long-acting beta agonists (LABA) in chronic obstructive pulmonary disease (COPD) and stop press covers the following:

Action: Clinicians will find this publication to be a useful review of current issues in drug safety.