- Prescribing Advice for GPs - https://www.prescriber.org.uk -

New contraindications for Bonviva

The European Medicines Agency (EMEA) has issued a press release detailing a recent recommendation to add two new contraindications for ibrandonic acid 150mg tablets (Bonviva®).

The existing contraindications of hypersensitivity and hypocalcaemia will be added to as follows:

The current Summary of Product Characteristics (SPC) advises that individuals with a history of prolonged oesophageal transit time should pay particular attention to the dosing instructions.

It is unlikely that any bisphosphonate would be used or tolerated in patients with these contraindications as they would be likely to experience gastrointestinal side effects such as dysphagia, oesophagitis and oesophageal or gastric ulcers. These recommended changes will simply provide clarification and clearer information for clinicians and patients.

Action: Clinicians should be aware of these recommended changes and ensure that ibrandonic acid is not being used in patients with these contraindications.