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Drug Safety Update - August 2010

The Medicines and Healthcare products Regulatory Agency (MHRA) has published Drug Safety Update for August 2010 (PDF).

This issue contains drug safety advice relating to QT and PR prolongation with saquinavir (Invirase®). Clinicians should be aware of this issue and avoid using saquinavir in patients at high risk of cardiac arrhythmias, and in patients using other drugs that may cause QT and/or PR interval prolongation. In patients already taking saquinavir care should be taken to avoid using other drugs that may cause QT and/or PR interval prolongation.

In the stop press section clinicians are reminded that:

Action: Clinicians will find this publication to be a useful review of current issues in drug safety.