- Prescribing Advice for GPs - https://www.prescriber.org.uk -

Drug Safety Update - February 2013

The Medicines and Healthcare products Regulatory Agency (MHRA) has published Drug Safety Update for February 2013 (PDF).

This update contains drug safety advice reminding clinicians of an increased risk of atypical femoral fractures have been reported rarely in patients with postmenopausal osteoporosis receiving long-term (longer than 2.5 years) treatment with denosumab 60mg (Prolia®). This debug is a human monoclonal antibody administered by injection every six months. It is recommended that:

Action: Clinicians will find this publication to be a useful review of current issues in drug safety.