- Prescribing Advice for GPs - https://www.prescriber.org.uk -

EMA recommends metoclopramide restrictions

The European Medicines Agency has recommended changes to the use of metoclopramide to reduce the risk of neurological side effects.

The review of metoclopramide, carried out at the request of the French medicines regulatory agency, confirmed the well-known risks of neurological effects including:

It was noted that the risk of side effects is increased at high doses or with long-term treatment.

The review has recommended that treatment duration is restricted to short-term use (up to 5 days) and that the maximum dose is limited (in adults to 10mg three times daily). It is also recommended that metoclopramide is not used in children under 1 year old.

Metoclopramide is only recommended for:

Action: Clinicians should be aware of these new restrictions and implement any necessary changes to current practice.

Thanks to Kevin Ashworth for spotting this article