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Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

Fluphenazine decanoate discontinued

The manufacturer of fluphenazine decanoate (Modecate®) injection has written to healthcare professionals advising that this product will be discontinued by the end of 2018.

The letter details unpredictable supplies of the active ingredient from the single global manufacturer as the reason for this decision. It is noted that this decision is not due to any safety concerns. Both injection strengths (25mg/ml and 100mg/ml) are being discontinued with manufacturing ceasing in mid-2018 with supplies in the United Kingdom expected to run out by the end of 2018.

Action: Clinicians should be aware of this product being discontinued. It would be prudent to run clinical system searches to identify any patients who are currently prescribed this product to allow a review and arrangements made to identify a suitable alternative.

Update: At the end of 2020 it seems that Modecate Concentrate 100mg/ml is still being manufactured and distributed in the UK.

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118 Comments to “Fluphenazine decanoate discontinued”

  1. Thank you Norma Monaghan. I am going to try and see if I could get this drug and send it to my brother. Sri Lanka is not having this medication. Ravi

    Comment by Ravi — May 25, 2022 #
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  2. My brother is having trouble in getting this injection in Sri Lanka? Is there a substitute?

    Comment by Ravi — May 24, 2022 #
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  3. Reading your messages has helped me a lot. I didn't realise how many others have suffered from the Modecate withdrawal, so cruel. It was the only medication that brought my daughter back to a near normal life. A joy for me her mother, and family, friends. Nothing else has worked, only at times Abilify, which stabilises, but is not long lastingly satisfactory. Thanks for the contact info - Germany, Hungary, etc. and for your comments - true, shame on Sanofi and the others, the sufferance they've caused us!

    Comment by Christine — May 23, 2022 #
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  4. It was a help to me to read all your messages. In fact, Modecate has good results on schizophrenic patients. I have the experience of my daughter, a chronic case for more than 15 yrs and since 2005, age 25 then. She was first prescribed Modecate in 2015 for a 3 month period, a wonderful return to normal life, and Abilify to follow up. It was tried again in 2018 for nearly a year, excellent - then the bad news, discontinued in 2019, such a disappointment. Since then she's had relapse after relapse - other medication doesn't work. The availability contacts, Germany, etc. have helped and above all I don't feel alone. Thanks.

    Comment by Christine Ann Chisman — May 23, 2022 #
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