Prescribing Advice for GPs

An NHS Prescribing Advisers' Blog

NICE Guidance - July 2020

The National Institute for Health and Care Excellence (NICE) have published new or updated guidance for the month of July 2020. This month are two guidelines and one medtech innovation briefing that impact upon primary care.

The COVID-19 rapid guideline: rheumatological autoimmune, inflammatory and metabolic bone disorders guideline has been updated. It aims to maximise the safety of children and adults with rheumatological autoimmune, inflammatory and metabolic bone disorders during the COVID-19 pandemic, while protecting staff from infection. It also enables services to make the best use of NHS resources. This update highlights the possible risk of adrenal crisis for patients on long-term corticosteroids.

The COVID-19 rapid guideline: arranging planned care in hospitals and diagnostic services guideline has been published. It aims to help healthcare professionals deliver efficient planned care while minimising the risk of COVID-19 in the context of increasing or decreasing local prevalence. It also aims to help patients make decisions about their planned care. It includes recommendations on social distancing and hand hygiene measures prior to planned care.

The Prontosan for acute and chronic wounds medtech innovation briefing has been published. This briefing notes that the intended place in therapy would be as an alternative to saline or water to cleanse wounds during dressing changes. The available evidence indicates that Prontosan is likely to be better than saline for treating acute and chronic wounds, but it is noted that the studies were of short duration and there could be significant resource implications depending on product type and quantity used.

Action: Clinicians should be aware of this month's new guidance and implement any necessary changes to practice.

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Which SGLT-2 Inhibitor?

There are currently four SGLT-2 inhibitors licensed for the treatment of diabetes. Canagliflozin, dapagliflozin, empagliflozin and ertugliflozin.

At the 2020 virtual conference of the America Diabetes Association the results of the cardiovascular outcomes study for ertugliflozin were released. This was the final drug in the group to release the results of a cardiovascular study although full publication in a peer reviewed medical journal is still pending.

We already know that these drugs are effective in reducing HbA1c, blood pressure and body weight. We also know that this group of medicines reduce hospital admissions for heart failure and renal function decline. However there is variation in the impact on cardiovascular outcomes. Empagliflozin reduced cardiovascular events and cardiovascular deaths; canagliflozin reduced cardiovascular events, but not deaths; while dapagliflozin was not statistically significant in either of these areas. This latter finding may be explained in part by the much higher proportion of patients without overt signs of cardiovascular disease (60% compared to 0% in the empagliflozin study and 35% and 50% in the canagliflozin studies).

So what does this new study add? It was conducted in just over 8,000 patients and exclusively in secondary prevention patients who were followed up for around 3 years. The study failed to demonstrate a reduction in major cardiovascular events compared to placebo. Nor did it show reductions in cardiovascular deaths or renal-related outcomes. It did demonstrate a 30% reduction in the risk of heart failure related hospital admission.

It was hoped that this study would mirror the results of the empagliflozin study and demonstrate reductions on cardiovascular endpoints and death, thus confirming a group of medicines that deliver cardiovascular benefits to patients with diabetes. Although previous and updated meta-analyses indicate there is a statistically significant reduction in cardiovascular events in secondary prevention patients, there is only a trend in primary prevention patients. And these findings are not replicated for all of these drugs in individual studies.

Based on the current evidence it would seem that this group of drugs do reduce hospital admission for heart failure. Furthermore, as a group, they also seem to reduce cardiovascular endpoints, cardiovascular deaths and renal outcomes. But there is only one drug in the group that has shown individually that it does all of these things in a single trial; and that drug is empagliflozin.

Based on the curent evidence then, it would seem prudent, despite ertugliflozin being less expensive, to use empagliflozin as the agent of choice in patients diabetes who need treatment intensification who:

  • also have established cardiovascular disease
  • are at risk of hospital admission for heart failure
  • are at risk of renal function decline

Patients who are not in one of these groups could be offered an SGLT-2 inhibitor of lowest acquisition cost as an option alongside other classes of drugs that are available to treat hyperglycaemia with discussion of the relative advantages and disadvantages before commencing treatment.

Action: Clinicians should be aware of the emerging evidence for this group of drugs and bases treatment decisions on the best available evidence.

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CKS Updates - June 2020

During June 2020 Clinical Knowledge Summaries were published or updated in the following areas.

All of the topics have been reviewed and undergone minor restructuring. The Vitiligo topic has been significantly restructured and recommendations have been updated in line with current evidence; several areas have been moved in line with CKS layout and the Prescribing information section now directs readers to the CKS topic on Corticosteroids - topical (skin), nose, and eyes.

Action: Clinicians who see patients with any of these conditions may find the new and updated information useful when reviewing current clinical practice.

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